For me it would have to be my wedding dress. Even with my bridesmaids holding it up for me it was still a hassle. I couldn't see my lower half either so it was a little tricky pulling down my underwear and back up again, and making sure I was sat far enough back on the toilet.
A wetsuit when on dry land. Not a problem when in the water as it is easy to just pee. However, if you feel the need to pee when on dry land then it is more of a problem as you pretty much have to take it completely off to get at the necessary parts. They are not the easiest of things to take off and replace either - especially when wet.
When I first started kayaking and wore wetsuits, I found it a bit of an issue because the intention in a kayak is that you ideally stay in the kayak